Scientists strive to develop artificial synthetic red cells, simulating the features that are excellent for natural cells, such as flexible shape transformation, oxygen transport, and long-operating lifecycle.
Most artificial red cells are now only a few, not all of the major features of natural prototypes.
Not long ago, on the San ACS Nano, a group of researchers published a report, said to have created artificial red cells, which have all the natural features of the cell and have added new features.
As it is known, these erythrocytes (RBC) absorb oxygen from the lungs and lead to body tissue cells. These cells (RBC) contain millions of hemoglobin (red blood cell) molecules – a protein containing iron to connect oxygen.
These red-cell cells are versatile, which can extend itself to pass through small capillaries and then recover back to their original shape. RBC cells that contain proteins on the surface can flow in long-time blood vessels without being swallowed up by immune cells.
Scientists Wei Zhu of South China University of Technology, C. Jeffrey Brinker of the University of New Mexico and colleagues developing new solutions, fabrication of artificial erythrocytes, has the same features as natural, but can also carry out new missions such as shipping drug treatment , which can be directed to the target by magnetic and detecting toxins in the body.
Researchers created synthetic cells by covering up RBCs of human blood donated by a thin layer of silica (take the unshaped silicon oxide).
Then, on the other the silica-RBC, the scientists used silica engraving solution to the porous form of silica upwards (there are more vulnerabilities and more flexibility, then use this silica sample to create copies. Eventually, scientists covered the surface of these copies with the natural RBC erythrocyte membrane.
These artificial cells have the same size, shape, charge and surface protein as natural red blood cells, especially that can extend shape when passing through small capillaries, then recover. revert to the original state. In mice, artificial synthetic red blood cells operated for more than 48 hours, were able to absorb oxygen and travel through blood vessels to tissues, not observed to have toxic effects on the body.
Scientists are trying to develop artificial synthetic red blood cells, simulating the amazing characteristic features of natural cells, such as flexible shape transformation, oxygen transport and life cycle. long action.
But so far, most artificial red blood cells have only a few, not all of the key features of natural prototypes.
Not long ago, in the journal ACS Nano, a team of researchers published a report, saying they created artificial red blood cells, which have all the natural features of a cell and There are more new features.
As known, red blood cells (RBC) absorb oxygen from the lungs and deliver it to body tissue. These disk-shaped (RBC) cells contain millions of molecules of hemoglobin (red blood cells) – a protein containing iron that binds to oxygen.
The red blood cells are very flexible, can stretch themselves to pass through small capillaries and then restore to their original shape. RBC cells that contain surface proteins can circulate in blood vessels for long periods without being swallowed up by immune cells.
Scientists Wei Zhu of South China University of Technology, C. Jeffrey Brinker of the University of New Mexico and colleagues developed a new solution, making artificial red blood cells, which have similar features as Naturally, but it can also carry out new missions such as transporting therapeutic drugs, which can target magnetic targets and detect toxins in the body.
The researchers created synthetic cells by coating RBCs of donated human blood with a thin layer of silica (amorphous silicon dioxide).
The researchers then applied positively and negatively charged polymers to the silica-RBCs, and the researchers used a silica etching solution to make the silica prototype porous (more porous and more flexible, then use the sample). This silica creates replicas, and the scientists eventually coat these clones with a natural layer of RBC red blood
cells, which are the size, shape, charge and surface protein. The face is similar to natural red blood cells, especially that can extend shape when passing through small capillaries, then restore to the original
state.In mice, artificial synthetic red blood cells work in over 48 hours, it is possible to absorb oxygen and travel through the blood vessels to tissues, not observed toxicity affecting the body.
Artificial red blood cells can carry drugs to the site of treatment and detect toxins in the body.
The researchers inserted artificial red blood cells with anti-cancer drugs, toxins sensors or magnetic nanoparticles and could act as bait to attract bacterial toxins. Future research will explore the endless potential of artificial cells in medical applications, such as cancer therapies and biotoxins.